Charles Dumontet Selected Research

5'-Nucleotidase (5' Nucleotidase)

10/2021	Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines.
9/2017	The cytosolic 5'-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells.
12/2016	Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.
12/2015	Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
7/2015	Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.
4/2014	Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies.
7/2003	Role of IMP-selective 5'-nucleotidase (cN-II) in hematological malignancies.
7/2002	Potential mechanisms of resistance to cytarabine in AML patients.

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Charles Dumontet Research Topics

Disease

116	Neoplasms (Cancer) 05/2022 - 02/2002
29	Breast Neoplasms (Breast Cancer) 02/2021 - 12/2002
17	Multiple Myeloma 01/2022 - 01/2002
12	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2011 - 01/2005
11	Leukemia 01/2022 - 07/2003
11	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 07/2002
8	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 07/2003
8	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 09/2017 - 08/2002
7	Lymphoma (Lymphomas) 01/2018 - 07/2002
7	Adenocarcinoma 09/2012 - 02/2002
6	Non-Hodgkin Lymphoma (Lymphosarcoma) 09/2017 - 07/2002
6	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 05/2017 - 10/2003
6	Carcinoma (Carcinomatosis) 01/2015 - 05/2006
5	Lung Neoplasms (Lung Cancer) 02/2021 - 01/2005
4	Neoplasm Metastasis (Metastasis) 12/2013 - 12/2006
4	Pancreatic Neoplasms (Pancreatic Cancer) 08/2013 - 10/2004
3	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 01/2003
3	Prostatic Neoplasms (Prostate Cancer) 12/2013 - 01/2007
2	Peripheral Nervous System Diseases (PNS Diseases) 05/2022 - 09/2016
2	Melanoma (Melanoma, Malignant) 01/2022 - 11/2010
2	Stomach Neoplasms (Stomach Cancer) 03/2021 - 02/2008
2	Hypoxia (Hypoxemia) 01/2021 - 05/2008
2	Carcinogenesis 01/2020 - 12/2009
2	Disease Progression 12/2013 - 08/2005

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
20	TubulinIBA 10/2012 - 12/2002
16	NucleosidesIBA 12/2016 - 07/2002
15	Gemcitabine FDA Link 08/2013 - 02/2002
13	Pharmaceutical PreparationsIBA 01/2022 - 02/2002
11	Biological ProductsIBA 02/2021 - 07/2002
10	NucleotidesIBA 02/2021 - 03/2004
9	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2019 - 04/2007
9	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2016 - 07/2002
8	Paclitaxel (Taxol)FDA LinkGeneric 05/2022 - 01/2005
8	5'-Nucleotidase (5' Nucleotidase)IBA 10/2021 - 07/2002
8	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 02/2015 - 09/2002
7	Messenger RNA (mRNA)IBA 01/2022 - 01/2003
7	Rituximab (Mabthera)FDA Link 01/2018 - 02/2007
7	fludarabineIBA 09/2017 - 07/2003
6	Tamoxifen FDA LinkGeneric 11/2019 - 03/2008
6	Taxoids (Taxanes)IBA 08/2010 - 01/2005
5	EnzymesIBA 02/2021 - 12/2005
5	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2005
5	Monoclonal AntibodiesIBA 01/2020 - 05/2009
5	Phosphotransferases (Kinase)IBA 01/2020 - 09/2005
5	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 03/2008
5	Estrogen ReceptorsIBA 05/2013 - 03/2009
5	Docetaxel (Taxotere)FDA Link 12/2012 - 12/2002
5	taxaneIBA 10/2012 - 01/2005
5	tau Proteins (tau Protein)IBA 08/2010 - 12/2002
4	Bortezomib (Velcade)FDA Link 05/2022 - 07/2013
4	AntibodiesIBA 01/2022 - 07/2012
4	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2010
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2020 - 04/2011
4	Cladribine FDA LinkGeneric 05/2017 - 01/2003
4	Vinorelbine (Navelbine)FDA LinkGeneric 02/2008 - 01/2005
4	Deoxycytidine KinaseIBA 10/2006 - 07/2002
3	Vincristine (Oncovin)FDA LinkGeneric 05/2022 - 04/2007
3	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 12/2003
3	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2021 - 10/2014
3	Immunoconjugates (Immunoconjugate)IBA 01/2020 - 07/2012
3	Cytotoxins (Cytolysins)IBA 01/2020 - 01/2004
3	Trastuzumab (Herceptin)FDA Link 01/2020 - 12/2012
3	Progesterone FDA LinkGeneric 12/2019 - 01/2011
3	Fulvestrant (Faslodex)FDA Link 11/2019 - 10/2008
3	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018 - 10/2013
3	PlatinumIBA 01/2018 - 10/2008
3	Glucose (Dextrose)FDA LinkGeneric 09/2017 - 01/2007
3	Dexamethasone (Maxidex)FDA LinkGeneric 09/2016 - 10/2008
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2014 - 03/2009
3	AnthracyclinesIBA 08/2011 - 06/2004
3	Progesterone Receptors (Progesterone Receptor)IBA 01/2011 - 03/2009
3	Estrogen Receptor alphaIBA 02/2009 - 03/2008
3	Nucleoside Transport Proteins (Nucleoside Transporter)IBA 09/2005 - 10/2004
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2022 - 01/2018
2	LigandsIBA 01/2022 - 01/2016
2	RNA (Ribonucleic Acid)IBA 01/2022 - 10/2009
2	Hormones (Hormone)IBA 04/2021 - 07/2009
2	Ado-Trastuzumab EmtansineIBA 03/2021 - 01/2020
2	Alkylating AgentsIBA 01/2021 - 07/2013
2	Immune Checkpoint InhibitorsIBA 01/2020 - 01/2018
2	Purine NucleosidesIBA 04/2019 - 05/2017
2	AntigensIBA 04/2019 - 04/2013
2	Histones (Histone)IBA 01/2018 - 10/2014
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018 - 12/2006
2	Small Interfering RNA (siRNA)IBA 09/2017 - 10/2009
2	Clofarabine (Clolar)FDA Link 05/2017 - 02/2013
2	2'-deoxyadenosineIBA 05/2017 - 11/2009
2	triphosphoric acid (triphosphate)IBA 05/2017 - 05/2009
2	SolutionsIBA 03/2016 - 11/2006
2	obinutuzumabIBA 01/2014 - 07/2012
2	Biomarkers (Surrogate Marker)IBA 08/2013 - 08/2010
2	Insulin-Like Growth Factor I (IGF-1)IBA 07/2013 - 01/2011
2	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 07/2011 - 08/2005
2	DeoxyribonucleotidesIBA 07/2011 - 07/2003

Therapy/Procedure

37	Therapeutics 01/2022 - 01/2002
34	Drug Therapy (Chemotherapy) 05/2022 - 07/2002
4	Adjuvant Chemotherapy 08/2010 - 01/2005
2	Ligation 01/2021 - 01/2015
2	Immunotherapy 11/2020 - 01/2018